Pathology of Malignant Pleural Mesothelioma

Thorac Surg Clin. 2020 Nov;30(4):367-382. doi: 10.1016/j.thorsurg.2020.08.007.

Abstract

Despite multiple diagnostic toolkits, the diagnosis of diffuse malignant pleural mesothelioma relies primarily on proper histologic assessment. The definitive diagnosis of diffuse malignant pleural mesothelioma is based on the pathologic assessment of tumor tissue, which can be obtained from core biopsy sampling, pleurectomy, or other more extensive resections, such as extrapleural pneumonectomy. Given its rarity and overlapping microscopic features with other conditions, the histologic diagnosis of diffuse malignant pleural mesothelioma is challenging. This review discusses the pathologic features and the differential diagnosis of diffuse malignant pleural mesothelioma, including select diagnostic pitfalls.

Keywords: BAP1; Biphasic; Differential diagnosis; Epithelioid; Immunohistochemistry; Mesothelioma; Pathology; Sarcomatoid.

Publication types

  • Systematic Review

MeSH terms

  • Biopsy
  • Diagnosis, Differential
  • Humans
  • Mesothelioma, Malignant / pathology*
  • Mesothelioma, Malignant / surgery
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / surgery
  • Thoracic Surgical Procedures