Simultaneous bilateral aqueous misdirection following certolizumab therapy for rheumatoid arthritis

BMJ Case Rep. 2020 Oct 4;13(10):e235194. doi: 10.1136/bcr-2020-235194.

Abstract

Aqueous misdirection syndrome is a rare, incompletely understood, sight-threatening eye condition that is difficult to diagnose and treat. We present a case of simultaneous bilateral aqueous misdirection following the administration of certolizumab in a 41-year-old women with rheumatoid arthritis and no known risk factors. To our knowledge, aqueous misdirection has not previously been associated with the use of tumour necrosis factor-alpha inhibitors.

Keywords: anterior chamber; drugs: musculoskeletal and joint diseases; glaucoma; iris; ophthalmology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anterior Chamber / diagnostic imaging*
  • Antirheumatic Agents / adverse effects
  • Antirheumatic Agents / therapeutic use
  • Aqueous Humor / drug effects
  • Aqueous Humor / metabolism*
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / drug therapy
  • Certolizumab Pegol / adverse effects*
  • Certolizumab Pegol / therapeutic use
  • Female
  • Glaucoma / chemically induced*
  • Glaucoma / diagnosis
  • Glaucoma / physiopathology
  • Humans
  • Intraocular Pressure / drug effects*
  • Intraocular Pressure / physiology
  • Visual Acuity*

Substances

  • Antirheumatic Agents
  • Certolizumab Pegol