The clinical utilities of multi-pinhole single photon emission computed tomography

Quant Imaging Med Surg. 2020 Oct;10(10):2006-2029. doi: 10.21037/qims-19-1036.


Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very successful application in small animal imaging, there has been a resurgence of the use of MPH collimators for clinical cardiac and brain studies, as well as other small field-of-view applications. This article reviews the basic principles of MPH collimators and introduces currently available and proposed clinical MPH SPECT systems.

Keywords: Single photon emission computed tomography (SPECT); brain; cardiac; collimator; multi-pinhole.

Publication types

  • Review