Temporal, Spatial, and Epidemiologic Relationships of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Gene Cycle Thresholds: A Pragmatic Ambi-directional Observation

Clin Infect Dis. 2021 Nov 2;73(9):e3133-e3135. doi: 10.1093/cid/ciaa1248.


Prospective serial sampling of 70 patients revealed clinically relevant cycle thresholds (Ct) occurring 9, 26, and 36 days after symptom onset. Race, gender, and corticosteroids apparently did not influence RNA positivity. In a retrospective analysis of 180 patients, initial Ct did not correlate with requirements for admission or intensive care.

Keywords: RNA positivity; SARS-CoV-2; corticosteroids; cycle threshold.

MeSH terms

  • COVID-19*
  • Hospitalization
  • Humans
  • Prospective Studies
  • Retrospective Studies
  • SARS-CoV-2*