How to approach adult patients with asymptomatic esophageal eosinophilia

Dis Esophagus. 2021 Jan 11;34(1):doaa105. doi: 10.1093/dote/doaa105.


As the awareness among gastroenterologists regarding endoscopic features suggesting eosinophilic esophagitis is increasing, individuals without symptoms of esophageal dysfunction are increasingly being found to have esophageal eosinophilia on biopsies performed during upper gastrointestinal endoscopies. However, the course of disease and the management of these asymptomatic individuals with esophageal eosinophilia remain elusive. In this review, we propose a definition of asymptomatic individuals with esophageal eosinophilia and discuss the prevalence, risk factors, and course of disease of this specific patient group. Furthermore, we have established a diagnostic and therapeutic pathway based on the most recent available data.

Keywords: eosinophilic esophagitis; eosinophilic gastrointestinal disorders; eosinophils.

Publication types

  • Review

MeSH terms

  • Adult
  • Biopsy
  • Endoscopy
  • Eosinophilic Esophagitis* / diagnosis
  • Humans
  • Prevalence