Mannich-type allylic C-H functionalization of enol silyl ethers under photoredox-thiol hybrid catalysis

Org Biomol Chem. 2021 Jan 6;19(1):141-145. doi: 10.1039/d0ob01862g.

Abstract

The synergy of an Ir-based photosensitizer with mild oxidizing ability and a thiol catalyst enables efficient allylic C-H functionalization of enol silyl ethers with imines under visible light irradiation. Subsequent transformations of the aminoalkylated enol silyl ethers allow for the facile construction of unique molecular frameworks such as functionalized octahydroisoindol-4-one.

Publication types

  • Research Support, Non-U.S. Gov't