Patient-Related Outcome Measures (PROMs) With Nonoperative and Operative Management of Morton's Neuroma

Foot Ankle Int. 2021 Feb;42(2):151-156. doi: 10.1177/1071100720961069. Epub 2020 Oct 5.


Background: Morton's neuroma is associated with chronic pain and disability. There is a paucity of literature regarding patient-related outcome measures (PROMs) in patients managed nonoperatively. We sought to investigate nonoperative and operative management of Morton's neuroma using PROMs in patients with follow-up to 1 year.

Methods: We conducted a prospective observational study and collected data on all patients with a new diagnosis of Morton's neuroma treated from February 2016 until April 2018. Primary outcome measures were the Manchester-Oxford Foot Questionnaire (MOXFQ) for pain, EuroQoL (EQ) time trade-off (TTO), and EQ visual analog scale (VAS) taken preoperatively and at 52 weeks postoperatively. Forty-four patients were treated nonoperatively and 94 patients were treated operatively.

Results: Pretreatment and 52-week scores were 55.7 and 43.10 (nonoperative) and 63.7 and 40.1 (operative) for MOXFQ (pain), 0.72 and 0.82 (nonoperative) and 0.68 and 0.82 (operative) for EQ-TTO, and 71.5 and 76.2 (nonoperative) and 73.1 and 68.7 (operative) for EQ-VAS. There was a statistically significant improvement in MOXFQ (pain) in nonoperative (P = .02) and operative groups (P < .001). There was a statistically significant improvement in EQ-TTO in the operative group only (P = .01).

Conclusion: This is the largest study investigating outcomes to 12 months of both nonoperative and operatively managed patients with Morton's neuroma. Both nonoperative and operative management lead to symptom improvement at 12 months.

Level of evidence: Level III, comparative study.

Keywords: Morton’s neuroma; forefoot; outcomes.

MeSH terms

  • Foot / physiology
  • Humans
  • Morton Neuroma / surgery*
  • Outcome Assessment, Health Care
  • Pain Measurement / methods
  • Postoperative Period
  • Prospective Studies
  • Retrospective Studies
  • Surveys and Questionnaires
  • Treatment Outcome
  • Visual Analog Scale