Appendiceal neoplasm incidence and mortality rates are on the rise in Australia

Expert Rev Gastroenterol Hepatol. 2021 Feb;15(2):203-210. doi: 10.1080/17474124.2021.1832467. Epub 2020 Nov 4.


Objectives: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia.

Methods: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y).

Results: Incidence and mortality rates of ANs increased significantly across both genders and age groups. Incidence rates increased by 415%, from 0.40/100 000 population in 1982 to 2.06/100 000 in 2013. Overall mortality rates increased by 130%, from 0.057/100 000 during 1982-1985 to 0.131/100 000 during 2010-2013. Controlling for age group and gender, the incidence rates increased by 20% every four years (Incidence rate ratio (IRR) = 1.20, 95% confidence interval (CI): 1.17, 1.23, global P value<0.0001), and controlling for age, the mortality rates increased by 8% every four years (IRR = 1.08, 95% CI: 1.00, 1.17, global P-value = 0.0401).

Conclusion: The increasing use of CT scanning, improvements in pathological assessment of the appendix, and the growing aging population may have contributed in part to the apparent rise in the incidence of ANs.

Keywords: Appendiceal neoplasms; incidence rates; mortality rates; risk factors.

Publication types

  • Video-Audio Media

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Appendiceal Neoplasms / epidemiology*
  • Appendiceal Neoplasms / mortality*
  • Australia / epidemiology
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sex Factors