MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells

Bone. 2021 Jan;142:115679. doi: 10.1016/j.bone.2020.115679. Epub 2020 Oct 3.

Abstract

MicroRNAs (miRNAs) have recently come under scrutiny for their role in various age-related diseases. Similarly, cellular senescence has been linked to disease and aging. MicroRNAs and senescence likely play an intertwined role in driving these pathologic states. In this review, we present the connection between these two drivers of age-related disease concerning mesenchymal stem cells (MSCs). First, we summarize key miRNAs that are differentially expressed in MSCs and other musculoskeletal lineage cells during senescence and aging. Additionally, we also reviewed miRNAs that are regulated via traditional senescence-associated secretory phenotype (SASP) cytokines in MSC. Lastly, we summarize miRNAs that have been found to target components of the cell cycle arrest pathways inherently activated in senescence. This review attempts to highlight potential miRNA targets for regenerative medicine applications in age-related musculoskeletal disease.

Keywords: Aging; Mesenchymal stem cells; MicroRNAs; Senescence.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cellular Senescence / genetics
  • Cytokines
  • Mesenchymal Stem Cells*
  • MicroRNAs* / genetics

Substances

  • Cytokines
  • MicroRNAs