Investigating the mechanism of ShuFeng JieDu capsule for the treatment of novel Coronavirus pneumonia (COVID-19) based on network pharmacology

Int J Med Sci. 2020 Sep 12;17(16):2511-2530. doi: 10.7150/ijms.46378. eCollection 2020.

Abstract

ShuFeng JieDu capsule (SFJDC), a traditional Chinese medicine, has been recommended for the treatment of COVID-19 infections. However, the pharmacological mechanism of SFJDC still remains vague to date. The active ingredients and their target genes of SFJDC were collected from TCMSP. COVID-19 is a type of Novel Coronavirus Pneumonia (NCP). NCP-related target genes were collected from GeneCards database. The ingredients-targets network of SFJDC and PPI networks were constructed. The candidate genes were screened by Venn diagram package for enrichment analysis. The gene-pathway network was structured to obtain key target genes. In total, 124 active ingredients, 120 target genes of SFJDC and 251 NCP-related target genes were collected. The functional annotations cluster 1 of 23 candidate genes (CGs) were related to lung and Virus infection. RELA, MAPK1, MAPK14, CASP3, CASP8 and IL6 were the key target genes. The results suggested that SFJDC cloud be treated COVID-19 by multi-compounds and multi-pathways, and this study showed that the mechanism of traditional Chinese medicine (TCM) in the treatment of disease from the overall perspective.

Keywords: Novel Coronavirus Pneumonia; ShuFeng JieDu capsule; candidate genes; network pharmacology, mechanism, pathway.

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Betacoronavirus*
  • COVID-19
  • Capsules / pharmacology
  • Caspase 3 / genetics
  • Caspase 8 / genetics
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / genetics
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / pharmacology*
  • Gene Expression / drug effects
  • Humans
  • Interleukin-6 / genetics
  • Mitogen-Activated Protein Kinase 1 / genetics
  • Pandemics
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / genetics
  • Protein Interaction Maps / drug effects*
  • Protein Interaction Maps / genetics
  • SARS-CoV-2
  • Transcription Factor RelA / genetics

Substances

  • Antiviral Agents
  • Capsules
  • Drugs, Chinese Herbal
  • IL6 protein, human
  • Interleukin-6
  • RELA protein, human
  • Transcription Factor RelA
  • shufeng jiedu
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1
  • CASP3 protein, human
  • CASP8 protein, human
  • Caspase 3
  • Caspase 8

Supplementary concepts

  • COVID-19 drug treatment