Total synthesis of thioamycolamide A via a biomimetic route

Org Biomol Chem. 2020 Nov 7;18(41):8366-8370. doi: 10.1039/d0ob01942a. Epub 2020 Oct 8.

Abstract

Thioamycolamide A is a biosynthetically unique cytotoxic cyclic microbial lipopeptide that bears a d-configured thiazoline, a thioether bridge, a fatty acid side chain, and a reduced C-terminus. Based on the biosynthetic insights, a concise total synthesis of thioamycolamide A was accomplished.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Lipopeptides*
  • Peptides, Cyclic*

Substances

  • Lipopeptides
  • Peptides, Cyclic
  • thioamycolamide A