Bilateral vestibulopathy: beyond imbalance and oscillopsia

J Neurol. 2020 Dec;267(Suppl 1):241-255. doi: 10.1007/s00415-020-10243-5. Epub 2020 Oct 8.


Objective: To optimize the current diagnostic and treatment procedures for patients with bilateral vestibulopathy (BV), this study aimed to determine the complete spectrum of symptoms associated with BV.

Method: A prospective mixed-method study design was used. Qualitative data were collected by performing semi-structured interviews about symptoms, context, and behavior. The interviews were recorded and transcribed until no new information was obtained. Transcriptions were analyzed in consensus by two independent researchers. In comparison to the qualitative results, quantitative data were collected using the Dizziness Handicap Inventory (DHI), Hospital Anxiety and Depression Scale (HADS) and a health-related quality of life questionnaire (EQ-5D-5L).

Results: Eighteen interviews were transcribed. Reported symptoms were divided into fourteen physical symptoms, four cognitive symptoms, and six emotions. Symptoms increased in many situations, such as darkness (100%), uneven ground (61%), cycling (94%) or driving a car (56%). These symptoms associated with BV often resulted in behavioral changes: activities were performed more slowly, with greater attention, or were avoided. The DHI showed a mean score of severe handicap (54.67). The HADS questionnaire showed on average normal results (anxiety = 7.67, depression = 6.22). The EQ-5D-5L demonstrated a mean index value of 0.680, which is lower compared to the Dutch age-adjusted reference 0.839 (60-70 years).

Conclusion: BV frequently leads to physical, cognitive, and emotional complaints, which often results in a diminished quality of life. Importantly, this wide range of symptoms is currently underrated in literature and should be taken into consideration during the development of candidacy criteria and/or outcome measures for therapeutic interventions such as the vestibular implant.

Keywords: Bilateral vestibular hypofunction; Bilateral vestibulopathy; Outcome measures; Symptoms; Vestibular implant; Vestibular prosthesis.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bilateral Vestibulopathy*
  • Child
  • Child, Preschool
  • Dizziness
  • Humans
  • Infant
  • Middle Aged
  • Prospective Studies
  • Quality of Life
  • Vertigo
  • Young Adult