Lung Clearance Index to Track Acute Respiratory Events in School-Age Children with Cystic Fibrosis

Abstract

Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in preschool children with cystic fibrosis (CF), but its utility to identify and manage these events in school-age children with CF is not well defined.Objectives: To describe changes in LCI with acute respiratory events in school-age children with CF.Methods: In a multisite prospective observational study, the LCI and FEV₁ were measured quarterly and during acute respiratory events. Linear regression was used to compare relative changes in LCI and FEV₁% predicted at acute respiratory events. Logistic regression was used to compare the odds of a significant worsening in LCI and FEV₁% predicted at acute respiratory events. Generalized estimating equation models were used to account for repeated events in the same subject.Measurements and Main Results: A total of 98 children with CF were followed for 2 years. There were 265 acute respiratory events. Relative to a stable baseline measure, LCI (+8.9%; 95% confidence interval, 6.5 to 11.3) and FEV₁% predicted (-6.6%; 95% confidence interval, -8.3 to -5.0) worsened with acute respiratory events. A greater proportion of events had a worsening in LCI compared with a decline in FEV₁% predicted (41.7% vs. 30.0%; P = 0.012); 53.9% of events were associated with worsening in LCI or FEV₁. Neither LCI nor FEV₁ recovered to baseline values at the next follow-up visit.Conclusions: In school-age children with CF, the LCI is a sensitive measure to assess lung function worsening with acute respiratory events and incomplete recovery at follow-up. In combination, the LCI and FEV₁ capture a higher proportion of events with functional impairment.

Keywords: early CF lung disease; lung clearance index; lung function recovery; multiple breath washout; pulmonary exacerbations.