Extramedullary Hematopoiesis in the Dura Mater During Treatment of a CNS Embryonal Tumor

J Pediatr Hematol Oncol. 2021 Nov 1;43(8):e1217-e1219. doi: 10.1097/MPH.0000000000001962.


Extramedullary hematopoiesis (EMH) is hematopoiesis occurring outside of the bone marrow. It has been reported to develop in abdominal organs or lymph nodes after chemotherapy. Here, the authors describe a patient with a localized central nervous system embryonal tumor who, during intensive chemotherapy, developed dural nodules. Biopsy revealed these nodules to be EMH. Without a pathologic diagnosis, this may have been considered disease progression, altering the patient's treatment plan. This report intends to serve as a reminder that EMH should be included in the differential diagnosis of suspicious lesions and highlights the importance of their biopsy because of potential management implications.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Central Nervous System Neoplasms / drug therapy*
  • Central Nervous System Neoplasms / pathology
  • Child, Preschool
  • Disease Progression
  • Dura Mater / drug effects
  • Dura Mater / pathology*
  • Hematopoiesis, Extramedullary*
  • Humans
  • Male
  • Neoplasms, Germ Cell and Embryonal / drug therapy*
  • Neoplasms, Germ Cell and Embryonal / pathology
  • Prognosis