Estriol in regulation of cell-mediated immune reactions in multiple sclerosis

J Neuroimmunol. 2020 Dec 15;349:577421. doi: 10.1016/j.jneuroim.2020.577421. Epub 2020 Sep 30.

Abstract

The effect of pregnancy hormone estriol (E3) on innate and adaptive immunity cells functions in patients with multiple sclerosis (MS) in comparison with healthy donors (HD) was studied. E3 inhibited phagocytic activity of neutrophils and enhanced monocytes IDO activity. Treg percentage increased and number of Th17 and iNKT cells decreased under E3 influence. At the same time, E3 stimulated production of IL-10 and inhibited secretion of IL-17. The hormonal effects were realized on the cells of both HD and MS patients. Thus, the MS amelioration during pregnancy may be related to E3 influence.

Keywords: Estriol; Indoleamine-2,3-dioxygenase; Multiple sclerosis; Phagocytosis; Regulatory T cells.

MeSH terms

  • Adaptive Immunity / drug effects
  • Adaptive Immunity / immunology*
  • Adult
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Estriol / pharmacology*
  • Female
  • Humans
  • Immunity, Cellular / drug effects
  • Immunity, Cellular / immunology*
  • Immunity, Innate / drug effects
  • Immunity, Innate / immunology*
  • Male
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / immunology*

Substances

  • Estriol