The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease

Sci Rep. 2020 Oct 8;10(1):16804. doi: 10.1038/s41598-020-72966-9.


A detailed description of pathophysiological effects that viruses exert on their host is still challenging. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully controllable environment, giving rise for new applications for the scientific community.

Publication types

  • Research Support, Non-U.S. Gov't
  • Video-Audio Media

MeSH terms

  • Cell Line
  • Doxycycline / pharmacology
  • Humans
  • Induced Pluripotent Stem Cells / virology*
  • Models, Biological
  • Myocytes, Cardiac / virology
  • RNA Virus Infections / virology*
  • RNA Viruses / physiology*
  • Virus Activation / drug effects


  • Doxycycline