Effect of piroxicam administration on outcome of frozen-thawed embryo transfer: A randomized, double-blinded, placebo-controlled trial

J Obstet Gynaecol Res. 2021 Jan;47(1):296-301. doi: 10.1111/jog.14521. Epub 2020 Oct 8.

Abstract

Aim: This study aimed to evaluate the effect of piroxicam adjuvant therapy on the clinical and biochemical pregnancy rate in patients undergoing in vitro fertilization (IVF) and frozen-thawed embryo transfer (ET) cycles.

Methods: In a randomized, double-blinded, placebo-controlled clinical trial, 178 patients eligible for IVF-ET received either single dose of piroxicam 1-2 h before frozen-thawed ET or a placebo at the same time. Study participants were then followed and compared regarding the primary outcome of the study, which was biochemical (positive β-human chorionic gonadotrophin test) and clinical pregnancy (detected fetal heart beat in ultrasound) rate.

Results: The results of this study indicated that there is no significant association between the piroxicam administration before frozen-thawed ET and the clinical or biochemical pregnancy rate (P = 0.208 and P = 0.699, respectively).

Conclusion: The findings of the current study suggest that piroxicam administration before ET has no beneficial effects on pregnancy rate among women undergoing IVF and frozen-thawed ET. However, further studies with larger sample sizes and longer follow-ups are recommended.

Keywords: embryo transfer; in vitro fertilization; nonsteroidal anti-inflammatory drugs; piroxicam; pregnancy.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Chorionic Gonadotropin, beta Subunit, Human
  • Cryopreservation
  • Double-Blind Method
  • Embryo Transfer*
  • Female
  • Fertilization in Vitro
  • Humans
  • Piroxicam*
  • Pregnancy
  • Pregnancy Rate

Substances

  • Chorionic Gonadotropin, beta Subunit, Human
  • Piroxicam