Total alkaloids from the rhizomes of Ligusticum striatum: a review of chemical analysis and pharmacological activities

Nat Prod Res. 2022 Jul;36(13):3489-3506. doi: 10.1080/14786419.2020.1830398. Epub 2020 Oct 9.


Rhizome Chuanxiong (RCX), the dried rhizomes of Ligusticum striatum DC., is a geoauthentic TCM herb distributed in Sichuan province of China that possesses efficacy in promoting blood circulation, removing blood stasis and alleviating pain. Rhizome Chuanxiong total alkaloids (RCXTAs) are one of the major characteristic constituents of RCX with the effects of antimigraine, neuroprotective, cardioprotective and other cardiovascular and cerebrovascular diseases. Over the past years, rapid development of technology has advanced some aspects of RCXTAs. The aim of this review is to illustrate the recent advances in the chemical analysis and biological activities of RCXTAs, and to highlight new challenges.

Keywords: Chemical analysis; Ligusticum striatum; Pharmacological activities; Total alkaloids.

Publication types

  • Review

MeSH terms

  • Alkaloids* / pharmacology
  • China
  • Drugs, Chinese Herbal* / pharmacology
  • Ligusticum*
  • Rhizome


  • Alkaloids
  • Drugs, Chinese Herbal