MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease: New and Potential Therapeutic Targets

Cardiol Clin. 2020 Nov;38(4):601-617. doi: 10.1016/j.ccl.2020.07.005. Epub 2020 Sep 17.


Noncoding RNAs (ncRNAs), including long noncoding RNAs and microRNAs, play an important role in coronary artery disease onset and progression. The ability of ncRNAs to simultaneously regulate many target genes allows them to modulate various key processes involved in atherosclerosis, including lipid metabolism, smooth muscle cell proliferation, autophagy, and foam cell formation. This review focuses on the therapeutic potential of the most important ncRNAs in coronary artery disease. Moreover, various other promising microRNAs and long noncoding RNAs that attract substantial scientific interest as potential therapeutic targets in coronary artery disease and merit further investigation are presented.

Keywords: Atherosclerosis; Long noncoding RNA; lncRNAs; miR-155; miR-33; miR-92a; miRNAs; microRNA.

Publication types

  • Review

MeSH terms

  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / metabolism
  • Coronary Artery Disease / therapy
  • Humans
  • Inflammation / genetics
  • Inflammation / prevention & control
  • MicroRNAs / metabolism*
  • RNA, Long Noncoding / metabolism*


  • MicroRNAs
  • RNA, Long Noncoding