When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

doi:10.1016/j.tcb.2020.09.002

Review

. 2020 Nov;30(11):881-891.

doi: 10.1016/j.tcb.2020.09.002. Epub 2020 Oct 6.

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Matías González-Quiroz¹, Alice Blondel², Alfredo Sagredo³, Claudio Hetz⁴, Eric Chevet², Rémy Pedeux⁵

Affiliations

¹ Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France.
² Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France.
³ Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
⁴ Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; The Buck Institute for Research in Aging, Novato, CA 94945, USA.
⁵ Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France. Electronic address: remy.pedeux@univ-rennes1.fr.

PMID: 33036871
DOI: 10.1016/j.tcb.2020.09.002

Free article

Review

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

Matías González-Quiroz et al. Trends Cell Biol. 2020 Nov.

Free article

. 2020 Nov;30(11):881-891.

doi: 10.1016/j.tcb.2020.09.002. Epub 2020 Oct 6.

Authors

Matías González-Quiroz¹, Alice Blondel², Alfredo Sagredo³, Claudio Hetz⁴, Eric Chevet², Rémy Pedeux⁵

Affiliations

¹ Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France.
² Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France.
³ Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
⁴ Biomedical Neuroscience Institute (BNI), Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health, and Metabolism (GERO), University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; The Buck Institute for Research in Aging, Novato, CA 94945, USA.
⁵ Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1242, Chemistry, Oncogenesis, Stress, and Signaling Laboratory, Université of Rennes 1, Rennes, France; Centre de Lutte contre le Cancer Eugène Marquis, Rennes, France. Electronic address: remy.pedeux@univ-rennes1.fr.

PMID: 33036871
DOI: 10.1016/j.tcb.2020.09.002

Abstract

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.

Keywords: ATM; DNA damage response; IRE1α; PERK; proteostasis; unfolded protein response.

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When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

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When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

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