Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review

Int Immunopharmacol. 2020 Oct 8;89(Pt A):107056. doi: 10.1016/j.intimp.2020.107056. Online ahead of print.

Abstract

Patchouli alcohol (PA), a tricyclic sesquiterpene, is a dominant bioactive component in oil extracted from the aerial parts of Pogostemon cablin (patchouli). Diverse beneficial activities have been reported, including anti-influenza virus, anti-depressant, anti-nociceptive, vasorelaxation, lung protection, brain protection, anti-ulcerogenic, anti-colitis, pre-biotic-like, anti-inflammatory, anti-cancer and protective activities against metabolic diseases. However, detailed mechanistic studies are required to explore the possibility of developing PA as a functional food material or promising drug for the prevention and treatment of human diseases. This review highlights multiple molecular targets and working mechanisms by which PA mediates health benefits.

Keywords: Biological mechanisms; Health benefits; Patchouli alcohol.

Publication types

  • Review