Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients

Biochemistry (Mosc). 2020 Jul;85(7):833-837. doi: 10.1134/S0006297920070111.

Abstract

Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 functions as a transcriptional repressor that inhibits expression of the inflammatory cytokines in macrophages. Critically ill patients with COVID-19 infection often present signs of high oxidative stress and systemic inflammation - the leading causes of mortality. This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Betacoronavirus*
  • COVID-19
  • Catechin / analogs & derivatives
  • Catechin / pharmacology
  • Catechin / therapeutic use
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / metabolism*
  • Coronavirus Infections / virology
  • Cytokines / antagonists & inhibitors*
  • Cytokines / metabolism*
  • Dimethyl Fumarate / pharmacology
  • Dimethyl Fumarate / therapeutic use
  • Female
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use
  • Inflammation / metabolism
  • Isothiocyanates / pharmacology
  • Isothiocyanates / therapeutic use
  • Male
  • Mice
  • Molecular Targeted Therapy / methods*
  • NF-E2-Related Factor 2 / metabolism*
  • Oxidative Stress / drug effects
  • Pandemics
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / metabolism*
  • Pneumonia, Viral / virology
  • Respiratory Distress Syndrome / drug therapy
  • Respiratory Distress Syndrome / metabolism
  • Respiratory Distress Syndrome / virology
  • Resveratrol / pharmacology
  • Resveratrol / therapeutic use
  • SARS-CoV-2
  • Signal Transduction / drug effects
  • Thiosulfates / pharmacology
  • Thiosulfates / therapeutic use

Substances

  • Antioxidants
  • Cytokines
  • Immunosuppressive Agents
  • Isothiocyanates
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • Thiosulfates
  • Catechin
  • epigallocatechin gallate
  • Dimethyl Fumarate
  • sulforaphane
  • sodium thiosulfate
  • Resveratrol

Supplementary concepts

  • COVID-19 drug treatment