Left Bundle Branch Block: A Reversible Pernicious Effect of Lacosamide

Monil M Majmundar; Tikal Kansara; Palak Shah; Harshvardhan Zala; Shobhana Chaudhari

doi:10.7759/cureus.10234

Left Bundle Branch Block: A Reversible Pernicious Effect of Lacosamide

Cureus. 2020 Sep 3;12(9):e10234. doi: 10.7759/cureus.10234.

Authors

Monil M Majmundar¹, Tikal Kansara¹, Palak Shah², Harshvardhan Zala³, Shobhana Chaudhari¹

Affiliations

¹ Department of Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.
² Department of Internal Medicine, Smt. B.K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth, Vadodara, IND.
³ Department of Internal Medicine, Amidhara Hospital, Surat, IND.

Abstract

A 95-year-old male with a medical history of focal epilepsy presented with transient ischemic attack (TIA)/pre-syncope like symptoms. He was on lacosamide (LCM) and levetiracetam. On evaluation, he was found to have left bundle branch block (LBBB), sinus pause of three seconds, and 1st degree atrioventricular (AV) block. After holding LCM, electrocardiogram changes were reversed to baseline (before commencing LCM). In conclusion, to the best of our knowledge, this is the first case of reversible LBBB along with sinoatrial (SA) node and AV node dysfunction in an elderly male on LCM therapy.

Keywords: av block; lacosamide; left bundle branch block; seizure; the sinus node.

Publication types

Case Reports