Thalamic Nuclei Volumes and Their Relationships to Neuroperformance in Multiple Sclerosis: A Cross-Sectional Structural MRI Study

Niels Bergsland; Ralph H B Benedict; Michael G Dwyer; Tom A Fuchs; Dejan Jakimovski; Ferdinand Schweser; Eleonora Tavazzi; Bianca Weinstock-Guttman; Robert Zivadinov

doi:10.1002/jmri.27389

Thalamic Nuclei Volumes and Their Relationships to Neuroperformance in Multiple Sclerosis: A Cross-Sectional Structural MRI Study

J Magn Reson Imaging. 2020 Oct 12;e27389. doi: 10.1002/jmri.27389. Online ahead of print.

Authors

Affiliations

¹ Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA.
² IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
³ Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA.
⁴ Center for Biomedical Imaging at Clinical Translational Science Institute, The State University of New York, Buffalo, New York, USA.

PMID: 33044013
DOI: 10.1002/jmri.27389

Abstract

Background: Although reduced thalamic volume is associated with multiple sclerosis (MS)-related clinical impairment, the role of individual thalamic nuclei remains poorly understood.

Purpose/hypothesis: To test whether individual thalamic nuclei volumes are more strongly associated with clinical disability than the whole thalamic volume.

Study type: Retrospective analysis of a prospective dataset.

Subjects: A total of 108 MS patients and 48 age- and sex-matched healthy controls (HCs) FIELD STRENGTH: 3T.

Sequences: 3D T₁ -weighted inversion recovery spoiled gradient echo; 2D T₂ -weighted fluid-attenuated inversion recovery spin echo; 2D dual-echo proton density-weighted/T₂ -weighted spin echo.

Assessments: Clinical assessments included the Expanded Disability Status Scale (EDSS), Nine-Hole Peg Test (9HPT), Timed 25-Foot Walk (T25FW), Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory Test-Revised (BVMTR), and the California Verbal Learning Test (CVLT2). FreeSurfer provided anterior, intralaminar, lateral, medial, ventral, posterior, and total volumes.

Statistical tests: False discovery rate-corrected partial correlations (controlling for age, sex, and education) to assess the relationships between volumes and neuroperformance.

Results: Compared to HCs, MS patients presented with lower thalamic nuclei volumes (P < 0.05) except for the intralaminar nucleus (P = 0.279) and scored worse on all neuroperformance scales (P ≤ 0.05) except for CVLT2 (P = 0.151). All nuclei except intralaminar were associated with EDSS (correlation coefficient range: -0.233 to -0.395), SDMT (range: 0.247-0.423), and 9HPT (range: -0.232 to -0.303) (all P < 0.05). BVMTR was associated with anterior (r = 0.319), lateral (r = 0.31), and medial (r = 0.304) volumes (all P < 0.05). T25FW correlated with ventral (r = -0.392) and total (r = -0.309) volumes (both P < 0.05), with the latter being significantly greater (P < 0.05).

Data conclusion: Assessing individual nuclei volume can aid in unraveling the relationship between thalamic pathology and disparate aspects of MS-related disability.

Level of evidence: 2 TECHNICAL EFFICACY STAGE: 2.

Keywords: atrophy; cognition; multiple sclerosis; thalamus.