Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update

Head Neck Pathol. 2021 Jun;15(2):608-616. doi: 10.1007/s12105-020-01234-z. Epub 2020 Oct 12.


Primary intraosseous oral squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that affects the jaws. Despite its aggressive biological behavior, there are no studies that evaluated the clinicopathological features of this tumor and parameters associated with its prognosis. The objective of the present study was to conduct a systematic review of the available data on oral and maxillofacial PIOSCC in order to determine its clinicopathological characteristics and biological behavior. We conducted a systematic review in May 2020 in multiple databases using a specific search strategy. Cases diagnosed as PIOSCC in the oral cavity and maxillofacial complex that had sufficient histopathological data, absence of ulceration in the oral mucosa, a negative result for a distant primary tumor, and radiographic evidence of an osteolytic lesion that was entirely or mostly surrounded by the jaw bones were included. A total of 109 published articles were included in our systematic review, corresponding to 257 cases. PIOSCC showed a male predilection (69.3%) and a preference for the mandible (7:1), with the posterior region being the most commonly affected site. The mean age at diagnosis was 57.3 years. Cortical expansion, pain, and lip/facial paresthesia were the most common clinical features. Regarding histopathological features, most PIOSCC were well-differentiated and the solid subtype was the most common. Statistical analysis showed that PIOSCC located in the mandible (p = 0.03) and recurrence (p < 0.01) were significantly associated with a higher mortality rate. PIOSCC has a poor prognosis, with high rates of mortality.

Keywords: Clinicopathological feature; Malignant neoplasm; Primary intraosseous squamous cell carcinoma; Prognosis.

Publication types

  • Systematic Review

MeSH terms

  • Female
  • Humans
  • Jaw Neoplasms / pathology*
  • Male
  • Middle Aged
  • Squamous Cell Carcinoma of Head and Neck / pathology*