Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial

Phytother Res. 2021 Feb;35(2):987-995. doi: 10.1002/ptr.6859. Epub 2020 Oct 12.


Grape seed extract (GSE) is a flavonoid-rich supplement, recently discussed as a potential moderator of inflammation and obesity. In this study, we aimed to investigate the effects of GSE supplementation along with a restricted-calorie diet (RCD), on changes in blood lipid profile, visceral adiposity index (VAI), and atherogenic index of plasma (AIP). We designed a randomized, double-blinded, placebo-controlled clinical trial. Forty obese or overweight individuals (25 ≤ body mass index < 40 kg/m2 ) were randomly assigned to receive GSE (300 mg/day) or placebo, plus RCD, for 12 weeks. We studied the anthropometric measures, biochemical biomarkers and dietary intake within the study timelines. Levels of high-density lipoprotein cholesterol (HDL-C) and HDL-C/low-density lipoprotein cholesterol (LDL-C) significantly increased in the GSE group as compared with the placebo group at week 12 (p = .03 and .008, respectively, adjusted for age, sex, energy and saturated fatty acid intake). We also observed a significant reduction in LDL-C following GSE supplementation in comparison to placebo (adjusted for age, sex and energy intake, p = .04). VAI, AIP, total cholesterol and triglyceride significantly decreased in the GSE group compared with the baseline (p = .04, .02, .01, and .02, respectively). GSE supplementation may have a modulatory role in improving blood lipid profile in obese or overweight individuals, when accompanied by RCD.

Keywords: HDL cholesterol; LDL cholesterol; body fat distribution; grape seed extract; obesity.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Caloric Restriction / methods*
  • Cardiovascular Diseases / drug therapy*
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Grape Seed Extract / pharmacology
  • Grape Seed Extract / therapeutic use*
  • Humans
  • Male
  • Obesity / drug therapy*
  • Overweight / drug therapy*
  • Risk Factors


  • Grape Seed Extract