Adenomatous neuroendocrine tumors of the middle ear (MEANTs) with local invasion and lymph nodes metastasis: A brief report of a rare neoplasm

Diagn Cytopathol. 2021 Apr;49(4):E141-E145. doi: 10.1002/dc.24640. Epub 2020 Oct 12.

Abstract

Adenomatous neuroendocrine tumors of the middle ear (MEANTs) are very rare neoplasms which are composed of both epithelial and neuroendocrine components. They have mostly bland histology and indolent biological behavior, yet they may recur and metastasize. Here we present a case of MEANT with ipsilateral local brain, bone and nerve invasion and bilateral cervical lymphadenopathy in a 48 years old male with history of recurrent chronic otitis media and cholesteatoma. The patient underwent an initial fine-needle aspiration biopsy (FNAB) of an enlarged cervical lymph node followed by surgical excision of the tumor and immunohistochemistry which confirmed the diagnosis.

Keywords: adenomatous neuroendocrine tumor; cytopathology; fine-needle aspiration biopsy; middle ear.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / pathology*
  • Biopsy, Fine-Needle
  • Ear Neoplasms / pathology*
  • Ear, Middle / pathology
  • Humans
  • Lymphatic Metastasis / pathology*
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neuroendocrine Tumors / pathology*