Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa

AIDS Res Hum Retroviruses. 2021 Jan;37(1):57-61. doi: 10.1089/AID.2020.0140. Epub 2020 Nov 23.


It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions -592 (C/A), -819 (C/T), and -1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.

Keywords: Africa; HIV; IL-10; Mali; SNPs; genetics; haplotypes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Genetic Predisposition to Disease
  • HIV Infections* / genetics
  • HIV-1* / genetics
  • Haplotypes
  • Humans
  • Interleukin-10 / genetics
  • Mali / epidemiology
  • Polymorphism, Single Nucleotide


  • IL10 protein, human
  • Interleukin-10