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, 92 (3), 547-9

Lung Immunogenicity, Rejection, and Obliterative Bronchiolitis

Lung Immunogenicity, Rejection, and Obliterative Bronchiolitis

C M Burke et al. Chest.

Abstract

Evidence suggests that obliterative bronchiolitis (OB) following human heart-lung transplantation is a form of allograft rejection related to augmented expression of class II major histocompatibility complex antigens (MHCII) on airway epithelium and mediated by activated T cells. Other forms of OB, including those related to viral infection and autoimmune disease, may reflect a similar mechanism.

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