From genoprotection to rejuvenation

Front Biosci (Landmark Ed). 2021 Jan 1;26:97-162. doi: 10.2741/4890.


Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient sensors including AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), the insulin/insulin-like IIGF) growth factor signaling pathway (IIS), sirtuins, NFkB, and FOXO. Aging can be delayed and life-span and health-span can be extended by calorie and dietary restrictions, administration of NAM, NMN, NR, NAD+, and by antioxidants including hydrogen sulfide. Additional measures for the age related decline in tissue homeostasis include senotherapeutics, senolytics, senomorphics, anti-inflammaging strategies, reactivation of telomerase and prevention of stem cell exhaustion. There is also a possibility to erase the signs of aging and even to reverse aging by epigenetic reprogramming and other emerging measures.

Publication types

  • Review

MeSH terms

  • Aging / genetics
  • Aging / physiology*
  • Animals
  • Epigenesis, Genetic
  • Humans
  • Longevity / physiology
  • Rejuvenation*
  • Signal Transduction