Modern Radiotherapy and Risk of Cardiotoxicity

Chemotherapy. 2020;65(3-4):65-76. doi: 10.1159/000510573. Epub 2020 Oct 13.


Despite the advancements of modern radiotherapy, radiation-induced heart disease remains a common cause of morbidity and mortality amongst cancer survivors. This review outlines the basic mechanism, clinical presentation, risk stratification, early detection, possible mitigation, and treatment of this condition.

Keywords: Cardiotoxicity; Radiation-induced heart disease; Radiotherapy.

Publication types

  • Review

MeSH terms

  • Cardiotoxicity
  • DNA Damage / radiation effects
  • Heart Diseases / diagnosis
  • Heart Diseases / etiology*
  • Humans
  • Neoplasms / radiotherapy*
  • Oxidative Stress / radiation effects
  • Radiation, Ionizing*
  • Risk Factors