Serological studies in Crohn's disease

Eur J Clin Microbiol. 1987 Jun;6(3):286-90. doi: 10.1007/BF02017614.


ELISA and immunofluorescence tests were carried out on sera from patients with Crohn's disease and ulcerative colitis. The results indicate that mean antibody levels to Yersinia enterocolitica types O:9 and O:3 and Klebsiella pneumoniae, but not Pseudomonas maltophilia, are significantly higher in these patients than in control subjects. There are differing antibody levels in ileal and colonic disease, and there is a significant fall in antibody levels 9-12 months after remission from clinical symptoms in patients providing serial serum samples. However, there is no correlation between the severity of the disease and antibody titres.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / analysis*
  • Colitis / immunology
  • Colitis / microbiology
  • Colitis, Ulcerative / immunology
  • Colitis, Ulcerative / microbiology
  • Crohn Disease / immunology*
  • Crohn Disease / microbiology
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique
  • Gram-Negative Bacteria / immunology
  • Humans
  • Ileitis / immunology
  • Ileitis / microbiology
  • Immunoglobulin G / analysis
  • Klebsiella pneumoniae / immunology*
  • Pseudomonas / immunology
  • Yersinia enterocolitica / immunology*


  • Antibodies, Bacterial
  • Immunoglobulin G