Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy for Remission of Type 2 Diabetes

J Clin Endocrinol Metab. 2021 Mar 8;106(3):922-933. doi: 10.1210/clinem/dgaa737.


Context: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the bariatric procedures most commonly used for the management of obesity. Whether one or the other is associated with a higher chance of remission of type 2 diabetes (T2D) is unclear.

Objective: This work aims to compare the efficacy of RYGB and SG for T2D remission at 1, 3, and 5 years after surgery.

Data sources: Four databases were searched until January 2020.

Study selection: Randomized controlled studies with at least 12 months of follow-up of patients with T2D allocated to RYGB or SG were selected.

Data extraction: To ensure uniformity, broad and narrow criteria for T2D remission were defined. The number of patients achieving remission of T2D at each assessment was extracted. Data were pooled using a random-effects model.

Data synthesis: Ten studies were included, evaluating 778 patients. The overall prevalence of achievement of broad and narrow criteria for T2D remission was 73% and 53% at the 1-year, 60% and 48% at the 3-year, and 51% and 43% at the 5-year assessment. Compared to SG, RYGB was associated with a higher chance of achieving broad and narrow criteria for remission at 1 year after surgery (risk ratio [RR] = 1.34 vs RR = 1.22) and broad criteria for remission at 5 years (RR = 1.18). No other differences were found.

Conclusions: The present meta-analysis suggests a more favorable effect of RYGB than SG on achieving T2D remission in the short-term only, although the evidence currently available does not clarify whether differences in this outcome are confirmed long term or fade thereafter.

Keywords: Roux-en-Y gastric bypass; lifestyle; meta-analysis; remission; sleeve gastrectomy; type 2 diabetes.

Publication types

  • Meta-Analysis

MeSH terms

  • Adult
  • Aftercare / statistics & numerical data
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / surgery*
  • Follow-Up Studies
  • Gastrectomy* / adverse effects
  • Gastrectomy* / methods
  • Gastrectomy* / statistics & numerical data
  • Gastric Bypass* / adverse effects
  • Gastric Bypass* / methods
  • Gastric Bypass* / statistics & numerical data
  • Humans
  • Prevalence
  • Randomized Controlled Trials as Topic / statistics & numerical data
  • Remission Induction / methods