Elevated TWIST1 expression in myelodysplastic syndromes/acute myeloid leukemia reduces efficacy of hypomethylating therapy with decitabine

Haematologica. 2020 Oct 1;105(10):e502. doi: 10.3324/haematol.2019.235325.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azacitidine / therapeutic use
  • Decitabine / therapeutic use
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / genetics
  • Myelodysplastic Syndromes* / drug therapy
  • Myelodysplastic Syndromes* / genetics
  • Nuclear Proteins / genetics
  • Twist-Related Protein 1

Substances

  • Nuclear Proteins
  • TWIST1 protein, human
  • Twist-Related Protein 1
  • Decitabine
  • Azacitidine

Grant support

Funding: the present study was supported by the National Natural Science Foundation of China (No. 81770123), the 13115 Key Projects of Scientific and Technical Innovation of Shaanxi Province (2010ZDKG-53), and Hundred-Talent Program of Shaanxi Province, and Youth Innovation Team of Shaanxi Universities.