High-throughput analysis of the T cell receptor gene repertoire in low-count monoclonal B cell lymphocytosis reveals a distinct profile from chronic lymphocytic leukemia

Andreas Agathangelidis; Chrysi Galigalidou; Lydia Scarfò; Theodoros Moysiadis; Alessandra Rovida; Elisavet Vlachonikola; Electra Sofou; Fotis Psomopoulos; Anna Vardi; Pamela Ranghetti; Alexandra Siorenta; Alex Galanis; Kostas Stamatopoulos; Anastasia Chatzidimitriou; Paolo Ghia

doi:10.3324/haematol.2019.221275

High-throughput analysis of the T cell receptor gene repertoire in low-count monoclonal B cell lymphocytosis reveals a distinct profile from chronic lymphocytic leukemia

Haematologica. 2020 Oct 1;105(10):e515. doi: 10.3324/haematol.2019.221275.

Authors

Affiliations

¹ Strategic Research Program on CLL and B-cell neoplasia Unit, Div. of Experimental Oncology, Milan.
² Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
³ Immunology and National Tissue Typing Center, General Hospital of Athens 'G. Gennimatas', Athens.
⁴ Department of Molecular Biology and Genetics (MBG), Democritus University of Thrace, Alexandroupolis.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

B-Lymphocytes
Genes, T-Cell Receptor
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Lymphocyte Count
Lymphocytosis* / diagnosis
Lymphocytosis* / genetics

Grants and funding

Funding: this project received funding from the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Technology (GSRT), under grant agreement n. 336 (Project CLLon); the TRANSCAN-2 Joint Transnational Call for Proposals 2014 (JTC 2014), GCH-CLL #143, by the European Commission/DG Research and Innovation; the project “KRIPIS II ODYSSEUS” funded by the Operational Programme "Competitiveness, Entrepreneurship and Innovation" (NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund); the Italian Association for Cancer Research (AIRC, Special Program on Metastasis, 5 per mille # 21198 to PG); PRIN 2015ZMRFEA, Italian Ministry of University and Research – MIUR, Roma, Italy ERA-NET TRANSCAN-2 JTC 2016 #179 NOVEL; open access project, ID number LM2011020, funded by the Ministry of Education, Youth and Sports of the Czech Republic under the activity “Projects of major infrastructures for research, development and innovations”.