Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

PLoS One. 2020 Oct 15;15(10):e0240402. doi: 10.1371/journal.pone.0240402. eCollection 2020.

Abstract

Background: The Japan Chronic Kidney Disease Database (J-CKD-DB) is a nationwide clinical database of patients with chronic kidney disease (CKD) based on electronic health records. The objective of this study was to assess the prevalences of hyperuricemia and electrolyte abnormalities in Japanese patients with CKD.

Methods: In total, 35,508 adult outpatients with estimated glomerular filtration rates of 5-60 ml/min/1.73 m2 in seven university hospitals were included this analysis. The proportions of patients with CKD stages G3b, G4, and G5 were 23.5%, 7.6%, and 3.1%, respectively.

Results: Logistic regression analysis showed that prevalence of hyperuricemia was associated with CKD stages G3b (adjusted odds ratio [95% confidence interval]: 2.12 [1.90-2.37]), G4 (4.57 [3.92-5.32]), and G5 (2.25 [1.80-2.80]). The respective prevalences of hyponatremia, hypercalcemia, hyperphosphatemia, and narrower difference between serum sodium and chloride concentrations were elevated in patients with CKD stages G3b, G4, and G5, compared with those prevalences in patients with CKD stage G3a. The prevalences of hyperkalemia were 8.3% and 11.6% in patients with CKD stages G4 and G5, respectively. In patients with CKD stage G5, the proportions of patients with optimal ranges of serum uric acid, potassium, corrected calcium, and phosphate were 49.6%, 73.5%, 81.9%, and 56.1%, respectively.

Conclusions: We determined the prevalences of hyperuricemia and electrolyte abnormalities in Japanese patients with CKD using data from a nationwide cohort study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Databases, Factual
  • Electrolytes / blood*
  • Female
  • Glomerular Filtration Rate
  • Hospitals, University
  • Humans
  • Hyperuricemia / complications
  • Hyperuricemia / epidemiology
  • Hyperuricemia / pathology*
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Renal Insufficiency, Chronic / complications
  • Renal Insufficiency, Chronic / epidemiology
  • Renal Insufficiency, Chronic / pathology*
  • Severity of Illness Index
  • Uric Acid / blood
  • Young Adult

Substances

  • Electrolytes
  • Uric Acid

Grant support

This work was supported in part by grants for Development of Comprehensive Database of Chronic Kidney Disease, Research on Policy Planning and Evaluation from the Ministry of Health, Labour and Welfare of Japan awarded to NK (H28-ICT-ippan-002, 19AC1002), and Japan Agency for Medical Research and Development, Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus and Platform Program for Promotion of Genome Medicine in the form of grants awarded to NK (20ek0210135h0001, 19ek0210095h0003, 20km0405210h0003).