Description of an influenza outbreak in a French university hospital and risk factors of nosocomial influenza

Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):879-884. doi: 10.1007/s10096-020-04070-9. Epub 2020 Oct 15.


Our objective was to evaluate risk factors of nosocomial influenza (NI) in an university hospital during the 2015/2016 influenza season. All hospitalized patients with influenza-like illness associated with laboratory confirmation by polymerase chain reaction were included in a prospective observational study. We identified 44 cases (19%) of NI among the 233 cases of influenza: 38/178 (21%) in adults and 6/55 (11%) in children. Among adults, hospitalization in a double or multi-occupancy room was independently associated with NI (adjusted Odds Ratio, 3.42; 95% CI, 1.29-9.08; p = 0.013). The results of the study underline the importance of single room to prevent NI.

Keywords: Influenza; Nosocomial; Risk factors; Seasonal outbreak.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Child, Preschool
  • Cross Infection / transmission*
  • Disease Outbreaks*
  • Female
  • France / epidemiology
  • Hospitals, University*
  • Humans
  • Infant
  • Influenza, Human / epidemiology*
  • Male
  • Middle Aged
  • Risk Factors