Unique surface structures of community-associated methicillin-resistant Staphylococcus aureus ST8/SCCmecIVl

Tsai-Wen Wan; Lee-Jene Teng; Tatsuo Yamamoto

doi:10.1016/j.jmii.2020.09.008

Unique surface structures of community-associated methicillin-resistant Staphylococcus aureus ST8/SCCmecIVl

J Microbiol Immunol Infect. 2021 Jun;54(3):527-530. doi: 10.1016/j.jmii.2020.09.008. Epub 2020 Oct 5.

Authors

Tsai-Wen Wan¹, Lee-Jene Teng², Tatsuo Yamamoto³

Affiliations

¹ Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Center, Niigata, Japan; Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
² Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
³ Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Center, Niigata, Japan. Electronic address: tatsuoy@imerc.jp.

PMID: 33060039
DOI: 10.1016/j.jmii.2020.09.008

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) threatens human health. A local CA-MRSA with ST8/SCCmecIVl (CA-MRSA/J) has emerged in Japan, being associated with progression from bullous impetigo to potentially fatal invasive infection. We found that CA-MRSA/J has unique bacterial surface structures, spikes, spikes with a cap, and long spikes, reflecting clinical origins.

Keywords: Bacteriophage; Community-associated methicillin-resistant Staphylococcus aureus; Spike; Surface structure.

MeSH terms

Community-Acquired Infections / microbiology*
Humans
Japan
Leukocidins / genetics
Methicillin-Resistant Staphylococcus aureus / chemistry*
Methicillin-Resistant Staphylococcus aureus / genetics
Methicillin-Resistant Staphylococcus aureus / ultrastructure
Microscopy, Electron
Staphylococcal Infections / microbiology

Substances

Leukocidins