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Review
. 2020 Sep 25:2020:5472096.
doi: 10.1155/2020/5472096. eCollection 2020.

The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms

Yalan Wu  1 , Suowen Xu  2 , Xiao Yu Tian  1
Affiliations
Free PMC article
Review

The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms

Yalan Wu et al. Oxid Med Cell Longev. .
Free PMC article

Abstract

Salvia miltiorrhiza (Danshen), as an important traditional Chinese medicinal plant, has been used in China for the treatment of cardiovascular diseases for hundreds of years. Salvianolic acids (salvianolic acid A and salvianolic acid B) as the most abundant water-soluble component extracted from Salvia miltiorrhiza have attracted more and more attention from cardiovascular scientists due to its comprehensive cardiovascular actions. In vivo and in vitro studies have rendered salvianolic acid an excellent drug candidate for the treatment and prevention of cardiovascular diseases. In this review, we surveyed the protective effects of salvianolic acid A and salvianolic acid B against cardiovascular diseases and the pharmacological basis, providing a strong scientific rationale for elucidating the important role of Salvia miltiorrhiza in cardiovascular therapy. More importantly, we also hope to provide new inspiration and perspectives on the development and innovation of small-molecule cardiovascular drugs based on salvianolic acid.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of salvianolic acid A (SalA) and salvianolic acid B (SalB).
Figure 2
Figure 2
The major signaling pathways involved in the vascular protection of salvianolic acid A (SalA) and salvianolic acid B (SalB).
See this image and copyright information in PMC

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