Saturable transport of peptides across the blood-brain barrier

Life Sci. 1987 Sep 14;41(11):1319-38. doi: 10.1016/0024-3205(87)90606-0.


Peptides can be transported across the blood-brain barrier by saturable transport systems. One system, characterized with radioactively labeled Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide), is specific for some of the small peptides with an N-terminal tyrosine, including Tyr-MIF-1, the enkephalins, beta-casomorphin, and dynorphin (1-8). Another separate system transports vasopressin-like peptides. The choroid plexus has at least one system distinguishable from those above that is capable of uptake and possibly transport of opiate-like peptides. The possibility of saturable transport of other peptides has been investigated to a varying degree. Specificity, stereo-specificity, saturability, allosteric regulation, modulation by physiologic and pharmacologic manipulations, and noncompetitive inhibition have been demonstrated to occur in peptide transport systems and suggest a role for them in physiology and disease.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aging
  • Aluminum / toxicity
  • Animals
  • Biological Transport
  • Blood-Brain Barrier*
  • Circadian Rhythm
  • Humans
  • Peptides / metabolism*
  • Stress, Physiological / physiopathology


  • Peptides
  • Aluminum