The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation

Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188453. doi: 10.1016/j.bbcan.2020.188453. Epub 2020 Oct 15.


Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This enzyme is involved in a plethora of cellular processes, including apoptosis, autophagy, cell proliferation, and DNA repair. Remarkably, PP2A can act as a context-dependent tumor suppressor or promoter. Active PP2A complexes consist of structural (PP2A-A), regulatory (PP2A-B), and catalytic (PP2A-C) subunits. The regulatory subunits define the substrate specificity and the subcellular localization of the holoenzyme. Here we condense the increasing evidence that the PP2A B-type subunit PR130 is a critical regulator of cell identity and oncogenic transformation. We summarize knowledge on the biological functions of PR130 in normal and transformed cells, targets of the PP2A-PR130 complex, and how diverse extra- and intracellular stimuli control the expression and activity of PR130. We additionally review the impact of PP2A-PR130 on cardiac functions, neuronal processes, and anti-viral defense and how this might affect cancer development and therapy.

Keywords: Cancer; PP2A; PPP2R3A; PR130; PR72; Signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • DNA Repair
  • Heart Function Tests
  • Humans
  • Protein Phosphatase 2 / genetics*
  • Protein Phosphatase 2 / metabolism*
  • Substrate Specificity


  • PPP2R3A protein, human
  • Protein Phosphatase 2