T cells show preferential adhesion to enteric neural cells in culture and are close to neural cells in the myenteric ganglia of Crohn's patients

J Neuroimmunol. 2020 Dec 15:349:577422. doi: 10.1016/j.jneuroim.2020.577422. Epub 2020 Oct 7.


Plexitis in the proximal margin of intestinal resections are associated with post-operative recurrence of Crohn's disease. To understand their formation, in vitro analyzes were performed. T cells adhered preferentially to neuron and glial cells in mixed primary cultures of enteric nervous system and T cell activation increased their adhesion capacity. Higher number of T lymphocytes in close proximity to enteric glial cells was also observed in the myenteric ganglia of Crohn's patients as compared to control. These data show that close proximity between lymphocytes and enteric neural cells exists and may contribute to the formation of plexitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Adhesion / physiology*
  • Cells, Cultured
  • Coculture Techniques
  • Crohn Disease / metabolism*
  • Crohn Disease / pathology
  • Enteric Nervous System / metabolism
  • Enteric Nervous System / pathology
  • Female
  • Ganglia / metabolism*
  • Ganglia / pathology
  • Humans
  • Myenteric Plexus / metabolism*
  • Myenteric Plexus / pathology
  • Neurons / metabolism*
  • Neurons / pathology
  • Pregnancy
  • Rats
  • Rats, Sprague-Dawley
  • T-Lymphocytes / metabolism*
  • T-Lymphocytes / pathology