A brief overview on recent advances in spiro[chromane-2,4'-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

Bioorg Med Chem. 2020 Dec 1;28(23):115813. doi: 10.1016/j.bmc.2020.115813. Epub 2020 Oct 10.

Abstract

The spiro[chromane-2,4'-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4'-piperidine]-4(3H)-one-derived compoundsin the recent years and focuses on features of their biological relevance's. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4'-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.

Keywords: 4′-piperidine]-4(3H)-one; Biological activity; Pharmacophores; Spiro[chromane-2; structure activity relationship (SAR).

MeSH terms

  • Acetyl-CoA Carboxylase / antagonists & inhibitors
  • Acetyl-CoA Carboxylase / metabolism
  • Antioxidants / chemistry
  • Carbonic Anhydrases / chemistry
  • Carbonic Anhydrases / metabolism
  • Chemistry, Pharmaceutical*
  • Chromans / chemistry*
  • Drug Design
  • Humans
  • Molecular Docking Simulation
  • Piperidines / chemistry*
  • Protein Isoforms / antagonists & inhibitors
  • Protein Isoforms / metabolism
  • Spiro Compounds / chemistry*
  • Spiro Compounds / metabolism
  • Structure-Activity Relationship

Substances

  • Antioxidants
  • Chromans
  • Piperidines
  • Protein Isoforms
  • Spiro Compounds
  • Carbonic Anhydrases
  • Acetyl-CoA Carboxylase