Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Adv Nutr. 2021 Mar 31;12(2):533-545. doi: 10.1093/advances/nmaa120.


Inflammatory bowel disease (IBD) is a group of chronic relapsing disorders whose etiology has not been fully explained. Therefore, available therapeutic approaches for IBD patients are still insufficient. Current treatment strategies are targeted to immune system dysfunctions, often associated with alternations in the microbiota, which contribute to the development of chronic intestinal inflammation. Therapeutics include anti-inflammatory drugs such as aminosalicylates and corticosteroids, immunosuppressive agents, antibiotics, and biological agents such as infliximab and vedolizumab. Auxiliary therapies involve a balanced and personalized diet, healthy lifestyle, avoiding stress, as well as dietary supplements. In this review, we discuss the use of bovine colostrum (BC) as a therapeutic agent, including its advantages and contraindications. We summarize our knowledge on well-researched BC constituents and their effects on the gastrointestinal tract as evidenced in in vitro and in vivo studies.

Keywords: IBD; bovine colostrum; cytokines; gastrointestinal; immunoglobulins; inflammatory bowel disease; treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Cattle
  • Colostrum*
  • Contraindications
  • Dietary Supplements
  • Female
  • Humans
  • Inflammatory Bowel Diseases* / drug therapy
  • Pregnancy


  • Anti-Inflammatory Agents