Comparison of manual and mechanical chest compression techniques using cerebral oximetry in witnessed cardiac arrests at the emergency department: A prospective, randomized clinical study

Am J Emerg Med. 2021 Mar:41:163-169. doi: 10.1016/j.ajem.2020.06.031. Epub 2020 Jun 28.


Aim: We aimed to compare regional cerebral oxygen saturation (rSO2) levels during cardiopulmonary resuscitation (CPR), performed either manually or using a mechanical chest compression device (MCCD), in witnessed cardiac arrest cases in the emergency department (ED), and to evaluate the effects of both the CPR methods and perfusion levels on patient survival and neurological outcomes.

Methods: This single-center, randomized study recruited patients aged ≥18 years who had witnessed a cardiopulmonary arrest in the ED. According to the relevant guidelines, CPR was performed either manually or using an MCCD. Simultaneously, rSO2 levels were continually measured with near-infrared spectroscopy.

Results: Seventy-five cases were randomly distributed between the MCCD (n = 40) and manual CPR (n = 35) groups. No significant difference in mean rSO2 levels was found between the MCCD and manual CPR groups (46.35 ± 14.04 and 46.60 ± 12.09, respectively; p = 0.541). However, a significant difference in rSO2 levels was found between patients without return of spontaneous circulation (ROSC) and those with ROSC (40.35 ± 10.05 and 50.50 ± 13.44, respectively; p < 0.001). In predicting ROSC, rSO2 levels ≥24% provided 100% sensitivity (95% confidence interval [CI] 92-100), and rSO2 levels ≥64% provided 100% specificity (95% CI 88-100). The area under the curve for ROSC prediction using rSO2 levels during CPR was 0.74 (95% CI 0.62-0.83).

Conclusion: A relationship between ROSC and high rSO2 levels in witnessed cardiac arrests exists. Monitoring rSO2 levels during CPR would be useful in CPR management and ROSC prediction. During CPR, MCCD or manual chest compression has no distinct effect on oxygen delivery to the brain.

Trial registration: identifier: NCT03238287.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain / metabolism*
  • Cardiopulmonary Resuscitation / methods*
  • Emergency Service, Hospital*
  • Female
  • Heart Arrest / therapy*
  • Humans
  • Male
  • Middle Aged
  • Oximetry*
  • Prospective Studies

Associated data