Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge

doi:10.1021/acsptsci.0c00141

. 2020 Sep 30;3(5):1039-1041.

doi: 10.1021/acsptsci.0c00141. eCollection 2020 Oct 9.

Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge

Amir Abdoli¹

Affiliations

PMID: 33073203
PMCID: PMC7552170
DOI: 10.1021/acsptsci.0c00141

Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge

Amir Abdoli. ACS Pharmacol Transl Sci. 2020.

. 2020 Sep 30;3(5):1039-1041.

doi: 10.1021/acsptsci.0c00141. eCollection 2020 Oct 9.

Author

Amir Abdoli¹

Affiliation

¹ Department of Parasitology and Mycology and Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

PMID: 33073203
PMCID: PMC7552170
DOI: 10.1021/acsptsci.0c00141

Abstract

Helminth infections are among the most common infectious diseases in underdeveloped countries. Helminths suppress the host immune responses and consequently mitigate vaccine efficacy and increase severity of other infectious diseases. Helminth co-infections might suppress the efficient immune response against SARS-CoV-2 at the early stage of the infection and may increase morbidity and mortality of COVID-19.

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Conflict of interest statement

The author declares no competing financial interest.

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References

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[1] Zhou F.; Yu T.; Du R.; et al. (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395 (10229), 1054–1062. 10.1016/S0140-6736(20)30566-3. - DOI - PMC - PubMed

[2] Zhou F.; Yu T.; Du R.; et al. (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395 (10229), 1054–1062. 10.1016/S0140-6736(20)30566-3. - DOI - PMC - PubMed

[3] Gazzinelli-Guimaraes P. H.; Nutman T. B. (2018) Helminth parasites and immune regulation. F1000Research 7, 1685.10.12688/f1000research.15596.1. - DOI - PMC - PubMed

[4] Gazzinelli-Guimaraes P. H.; Nutman T. B. (2018) Helminth parasites and immune regulation. F1000Research 7, 1685.10.12688/f1000research.15596.1. - DOI - PMC - PubMed

[5] Hay S. I.; Abajobir A. A.; Abate K. H.; et al. (2017) Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390 (10100), 1260–1344. 10.1016/S0140-6736(17)32130-X. - DOI - PMC - PubMed

[6] Hay S. I.; Abajobir A. A.; Abate K. H.; et al. (2017) Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390 (10100), 1260–1344. 10.1016/S0140-6736(17)32130-X. - DOI - PMC - PubMed

[7] Allen J. E.; Maizels R. M. (2011) Diversity and dialogue in immunity to helminths. Nat. Rev. Immunol. 11 (6), 375–388. 10.1038/nri2992. - DOI - PubMed

[8] Allen J. E.; Maizels R. M. (2011) Diversity and dialogue in immunity to helminths. Nat. Rev. Immunol. 11 (6), 375–388. 10.1038/nri2992. - DOI - PubMed

[9] Salgame P.; Yap G. S.; Gause W. C. (2013) Effect of helminth-induced immunity on infections with microbial pathogens. Nat. Immunol. 14 (11), 1118–1126. 10.1038/ni.2736. - DOI - PMC - PubMed

[10] Salgame P.; Yap G. S.; Gause W. C. (2013) Effect of helminth-induced immunity on infections with microbial pathogens. Nat. Immunol. 14 (11), 1118–1126. 10.1038/ni.2736. - DOI - PMC - PubMed

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Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge

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Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge

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