Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis

Biomolecules. 2020 Oct 15;10(10):1449. doi: 10.3390/biom10101449.


Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fluidity, which mediates cellular function. Phospholipases and the bioactive lipids they produce are important regulators of immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression, respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.

Keywords: T cells; atherosclerosis; lipins; macrophages; phospholipases.

Publication types

  • Review