Sex-biased Immune Responses Following SARS-CoV-2 Infection

Trends Microbiol. 2020 Dec;28(12):952-954. doi: 10.1016/j.tim.2020.10.002. Epub 2020 Oct 10.


Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucidating the mechanisms that underlie the male bias in severe disease and death from coronavirus disease 2019 (COVID-19).

Keywords: COVID-19; SARS-CoV-2; biological sex; immunopathogenesis.

Publication types

  • Comment

MeSH terms

  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections*
  • Female
  • Humans
  • Male
  • Pandemics*
  • Pneumonia, Viral*
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome*