Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease

Lawrence T C Ong; David R Booth; Grant P Parnell

doi:10.1002/mnfr.202000437

Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease

Mol Nutr Food Res. 2020 Dec;64(23):e2000437. doi: 10.1002/mnfr.202000437. Epub 2020 Oct 29.

Authors

Lawrence T C Ong^{1

2}, David R Booth¹, Grant P Parnell¹

Affiliations

¹ Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, The University of Sydney, 176 Hawkesbury Rd, Westmead, New South Wales, 2145, Australia.
² Department of Immunology, Westmead Hospital, Cnr Darcy and Hawkesbury Rds, Westmead, New South Wales, 2145, Australia.

PMID: 33079481
DOI: 10.1002/mnfr.202000437

Abstract

DNA methylation is increasingly being recognized as a mechanism through which environmental exposures confer disease risk. Several studies have examined the association between vitamin D and changes in DNA methylation in areas as diverse as human and animal development, genomic stability, chronic disease risk, and malignancy. In many cases, they have demonstrated clear associations between vitamin D and DNA methylation in candidate disease pathways. Despite this, a clear understanding of the mechanisms by which these factors interact is unclear. This paper reviews the current understanding of the effects of vitamin D on DNA methylation. In light of current knowledge in the field, the potential mechanisms mediating vitamin D effects on DNA methylation are discussed, as are the limiting factors and future avenues for research into this exciting area.

Keywords: DNA methylation; calcidiol; calcitriol; epigenetics; vitamin D.

Publication types

Review