Immunology: How the Microbiota Digests Bile to Protect against Viral Infection

Kendra Klag; June L Round

doi:10.1016/j.cub.2020.08.044

Immunology: How the Microbiota Digests Bile to Protect against Viral Infection

Curr Biol. 2020 Oct 19;30(20):R1271-R1272. doi: 10.1016/j.cub.2020.08.044.

Authors

Kendra Klag¹, June L Round²

Affiliations

¹ Department of Pathology, University of Utah School of Medicine, Division of Microbiology and Immunology, Huntsman Cancer Institute, UT 84112, USA.
² Department of Pathology, University of Utah School of Medicine, Division of Microbiology and Immunology, Huntsman Cancer Institute, UT 84112, USA. Electronic address: june.round@path.utah.edu.

Abstract

In a recent issue of Cell, Winkler et al. provide a comprehensive analysis of how secondary bile acids produced by unique members of the microbiota regulate plasmacytoid dendritic cells and monocytes via TLR7 and MyD88 signaling to protect from alphavirus dissemination.

Publication types

Comment

MeSH terms

Alphavirus Infections*
Bile / metabolism
Bile Acids and Salts
Dendritic Cells / metabolism
Gastrointestinal Microbiome*
Humans
Microbiota*
Myeloid Differentiation Factor 88 / metabolism
Toll-Like Receptor 7 / metabolism

Substances

Bile Acids and Salts
Myeloid Differentiation Factor 88
Toll-Like Receptor 7

Grants and funding

T32 DK091317/DK/NIDDK NIH HHS/United States